Author

M. Niphakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. j. O'Donoghue· 1 shared A. S. Bhatt· 1 shared B. Cravatt· 1 shared C. Dixon· 1 shared D. J. Gelsinger· 1 shared F. Faucher· 1 shared G. D. Fairn· 1 shared K. Huang· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. j. O'Donoghue

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2 papers

Recent·Most cited

Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohns disease-associated NOD2 variants.

C. Dixon, N. Martin, M. Niphakis, B. Cravatt, G. D. Fairn

This study identifies ABHD17 isoforms as deacylases of NOD2, showing that inhibiting them enhances NOD2 membrane localization and function in Crohn's disease-associated variants.

bioRxiv · Dec 20, 2023Immunology

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

L. J. Keller, T. H. Nguyen, L. Liu, M. Lakemeyer, D. J. Gelsinger, R. Chanin, N. Ngo, K. M. Lum, F. Faucher, P. Ipock, M. Niphakis, A. S. Bhatt, A. j. O'Donoghue, K. Huang, M. Bogyo

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology