Author

B. Cravatt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

B. Melillo· 2 shared D. Ogasawara· 2 shared E. Njomen· 2 shared G. Simon· 2 shared H. Li· 2 shared J. Teijaro· 2 shared K. DeMeester· 2 shared M. Dix· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

B. Melillo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

D. Ogasawara, D. Konrad, Z. Y. Tan, K. Carey, J. Luo, S. J. Won, H. Li, T. Carter, K. DeMeester, E. Njomen, S. Schreiber, R. Xavier, B. Melillo, B. Cravatt

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

bioRxiv · Feb 27, 2024Biochemistry

Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohns disease-associated NOD2 variants.

C. Dixon, N. Martin, M. Niphakis, B. Cravatt, G. D. Fairn

This study identifies ABHD17 isoforms as deacylases of NOD2, showing that inhibiting them enhances NOD2 membrane localization and function in Crohn's disease-associated variants.

bioRxiv · Dec 20, 2023Immunology

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

E. Vinogradova, D. Lazar, R. Suciu, Y. Wang, G. Bianco, Y. Yamashita, V. Crowley, D. Remillard, K. Lum, G. Simon, E. Kemper, M. Lazear, S. Yin, M. Blewett, M. Dix, , B. Cravatt

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.

bioRxiv · Oct 17, 2019 · PreprintImmunology