Author

K. M. Lum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M. Bogyo· 2 shared M. J. Niphakis· 2 shared M. Lakemeyer· 2 shared N. Ngo· 2 shared A. Inguva· 1 shared A. J. Firestone· 1 shared A. j. O'Donoghue· 1 shared A. Long· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

M. Bogyo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

L. J. Keller, T. H. Nguyen, L. Liu, M. Lakemeyer, D. J. Gelsinger, R. Chanin, N. Ngo, K. M. Lum, F. Faucher, P. Ipock, M. Niphakis, A. S. Bhatt, A. j. O'Donoghue, K. Huang, M. Bogyo

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology

Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host

O. Onguka, B. M. Babin, M. Lakemeyer, I. T. Foe, N. Amara, S. M. Terrell, K. M. Lum, P. Cieplak, M. J. Niphakis, J. Z. Long, M. Bogyo

This study identifies serine hydrolases in Toxoplasma gondii that hydrolyze lipid esters, showing their role in lipid metabolism and potential as therapeutic targets.

bioRxiv · Nov 24, 2020Microbiology

ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth

J. R. Remsberg, R. M. Suciu, N. A. Zambetti, T. W. Hanigan, A. J. Firestone, A. Inguva, A. Long, N. Ngo, K. M. Lum, C. L. Henry, S. K. Richardson, M. Predovic, B. Huang, A. R. Howell, M. J. Niphakis, , B. F. Cravatt

This study identifies ABD957, a selective ABHD17 inhibitor, which disrupts N-Ras depalmitoylation and inhibits NRAS-mutant AML growth, suggesting potential as a targeted therapy.

bioRxiv · May 21, 2020Cancer Biology