Epithelial cell biomarkers are predictive of response to biologic agents in Crohn's disease
M. Osterman, K. VanDussen, I. O. Gordon, E. M. Davis, K. Li, K. Simpson, M. Ciorba, B. P. Abraham, X. Guo, E. Yee, F. Allard, , J. G. Jacqueline G. Perrigoue, B. Claggett, B. Shen, T. S. Stappenbeck, J. J. Liu
The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.
bioRxiv · May 20, 2020Cell Biology