K. Li

Looking backward for the future: long-term population recovery, habitat associations, and future climatic vulnerability of the critically endangered Sino-Mongolian beaver (Castor fiber birulai) in China

This study tracks the population recovery and habitat preferences of the Sino-Mongolian beaver and assesses future climatic vulnerability using historical and projected data.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies

This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.

An off-lattice discrete model to characterise filamentous yeast colony morphology

The paper uses an off-lattice agent-based model and experimental data to show that budding mechanisms and nutrient concentration drive filamentous yeast colony morphology.

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

The murine lung microbiome is dysbalanced by the human pathogenic fungus Aspergillus fumigatus resulting in enrichment of anaerobic bacteria

This study shows that Aspergillus fumigatus infection in immunosuppressed mice disrupts lung microbiome balance, increasing anaerobic bacteria like Ligilactobacillus murinus, which can be internalized by epithelial cells.

The brassinosteroid receptor gene BRI1 safeguards cell-autonomous brassinosteroid signaling across tissues

This study shows that BRI1 expression in multiple tissues is necessary but not sufficient for brassinosteroid signaling, suggesting cell-autonomous receptor function.

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection

The paper identifies that splenic red pulp macrophages, aided by natural antibodies and complement, clear liver-resistant Streptococcus pneumoniae from the bloodstream in mice.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Dual-view jointly learning improves personalized drug synergy prediction

This paper introduces JointSyn, a dual-view learning method for predicting drug synergy, showing improved accuracy and generalization across datasets.

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Hexose transporters CsHT3/16 involved in post-phloem transport and affected cucumber fruit development

The paper identifies CsHT3/16 as key hexose transporters in cucumber fruit development, showing their role in sugar homeostasis and fruit size regulation through expression patterns and mutant analysis.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

Interplay between harvesting, planting density and ripening time affects coffee leaf rust dispersal and infection

This study models how coffee harvesters' movement patterns, influenced by planting density and ripening time, affect coffee leaf rust dispersal and infection levels.

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming

This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

SETD2 maintains nuclear lamina stability to safeguard the genome

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

Novel Epidermal Oxysterols Function as Alarm Substances in Zebrafish

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Structural basis for the ligand recognition and signaling of free fatty acid receptors

The paper determines the structures of FFA1 and FFA4 bound to fatty acids and elucidates their activation mechanisms through cryo-EM and computational methods.

Mechanical force regulates ligand binding and function of PD-1

This study shows mechanical force is critical for PD-1 function, as soluble PD-L1 lacks the mechanical support needed to trigger PD-1 signaling.

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

snoRNA-guided tRNA 2'-O-methylation controls codon-biased gene expression and cellular states

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

The paper models histological transformation of lung cancer and identifies neuroendocrine-specific tolerance to Myc as an oncogenic driver.