B. Shen

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Dual-view jointly learning improves personalized drug synergy prediction

This paper introduces JointSyn, a dual-view learning method for predicting drug synergy, showing improved accuracy and generalization across datasets.

The 15-min (Sub)Cellular Proteome

The paper introduces a fast proteomic method using CE-DIA MS to profile the subcellular proteome of single cells with high sensitivity and coverage.

Regulatory T cells and IFN-γ-producing Th1 cells play a critical role in the pathogenesis of Sjögren's Syndrome

This study identifies Treg cells and IFN-γ-producing Th1 cells as key drivers of Sjögren's Syndrome pathogenesis using a mouse model and single-cell transcriptomics.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

This study identifies evolutionarily new genes in humans with disease phenotypes, showing their enrichment in male reproductive diseases and adaptive traits like brain size and color vision.

An Artificial Intelligence-Assisted Digital Microfluidic System for Multistate Droplet Control

This paper introduces an AI-assisted digital microfluidic system called DropAI for multistate droplet control using semantic segmentation and state machine feedback.

Bibliometric and Temporal Trend Analysis of Nipah Virus- An Emerging Zoonotic Disease: What Do We Know So Far

This paper conducts a bibliometric and temporal trend analysis of Nipah virus research, revealing increased publication rates and highlighting gaps in drug and vaccine development.

Phylogenetically diverse wild plant species use common biochemical strategies to thrive in the Atacama Desert

The paper identifies common biochemical strategies across phylogenetically diverse Atacama Desert plant species adapted to extreme conditions.

Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

High-performance GPCR optogenetics based on molecular properties of animal opsins, MosOpn3 and LamPP

This study evaluates two animal opsins, MosOpn3 and LamPP, for GPCR optogenetics in C. elegans, showing high sensitivity and color-dependent behavioral control.

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

This paper evaluates BOXR1030, a CAR T cell therapy co-expressing GPC3-targeted CAR and GOT2, showing enhanced T cell metabolism and improved antitumor activity in preclinical models.

FANCD2 and RAD51 recombinase directly inhibit DNA2 nucleases at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability

This study shows FANCD2 inhibits DNA2 nuclease activity and stabilizes RAD51 filaments to protect stalled replication forks, promoting genome stability.

Sequencing uracil in DNA at single-nucleotide resolution

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

High throughput functional screening for next generation cancer immunotherapy using droplet-based microfluidics

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

Epithelial cell biomarkers are predictive of response to biologic agents in Crohn's disease

The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.

Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

This study characterizes and optimizes doxorubicin loading into DNA origami nanostructures, revealing rapid binding and variable release profiles influenced by nanostructure design and environmental factors.

YTHDF1 drives intestinal immune response against bacterial infection

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

The effect of APOBEC3B deaminase on double-stranded DNA

This study shows APOBEC3B can deaminate C in double-stranded DNA under specific conditions and enhances alkylating agent-induced breaks without requiring deaminase activity.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.

A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

RAD51 AND MITOTIC FUNCTION OF MUS81 ARE ESSENTIAL FOR RECOVERY FROM LOW-DOSE OF CAMPTOTHECIN IN THE ABSENCE OF THE WRN EXONUCLEASE

The paper investigates how WRN exonuclease deficiency affects replication fork recovery from camptothecin, showing RAD51 and MUS81 mitotic function are essential to prevent genome instability.