Author

M. Packer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. Mattos· 1 shared D. Gyawali· 1 shared D. P. Donnelly· 1 shared H. Guterres· 1 shared J. A. Parker· 1 shared J. K. Chung· 1 shared J. N. Agar· 1 shared J. Schariter· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

C. Mattos

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2 papers

Recent·Most cited

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems.

M. Packer, D. Gyawali, R. Yerabolu, J. Schariter, P. White

This study identifies an electrophilic impurity in lipid nanoparticles that modifies mRNA, rendering it untranslatable and reducing protein expression.

bioRxiv · Sep 21, 2021Biochemistry

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics