Author

L. Makowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:mouse· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. N. Hayes· 2 shared L. M. Sipe· 2 shared M. Chaib· 2 shared U. Tanveer· 2 shared A. A. Bashit· 1 shared A. K. Pingili· 1 shared B. R. Counts· 1 shared B. Teng· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

D. N. Hayes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Small-angle x-ray microdiffraction from fibrils embedded in tissue thin sections

P. Nepal, A. A. Bashit, L. Yang, L. Makowski

This paper proposes strategies to extract fibril structure and tissue organization information from SAXS data of fibrils in tissue thin sections, leveraging micro- and nano-beam x-ray scattering.

bioRxiv · May 10, 2022Biophysics

Protein Kinase C Delta Regulates Mononuclear Phagocytes and Hinders Response to Immunotherapy in Cancer

M. Chaib, J. R. Holt, L. M. Sipe, M. S. Bohm, S. C. Joseph, J. Yarbro, U. Tanveer, T. J. Hollingsworth, Q. Wei, P. Thomas, D. N. Hayes, L. Makowski

This study shows that PKCδ in mononuclear phagocytes suppresses antitumor immunity and response to immunotherapy by reprogramming macrophages and dendritic cells.

bioRxiv · Mar 31, 2022Immunology

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

L. M. Sipe, M. Chaib, E. B. Korba, M. C. Lovely, H. Jo, B. R. Counts, U. Tanveer, J. C. Clements, N. A. John, D. Daria, T. N. Marion, R. Sekhri, A. K. Pingili, B. Teng, J. A. Carson, , L. Makowski

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

bioRxiv · Mar 30, 2022Cancer Biology

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics

Dynamics of chromosome replication and its relationship to predatory attack lifestyles in Bdellovibrio bacteriovorus

L. Makowski, D. Trojanowski, R. Till, C. Lambert, R. Lowry, R. E. Sockett, J. Zakrzewska-Czerwinska

This paper investigates the dynamics of chromosome replication in Bdellovibrio bacteriovorus during its reproductive phase, revealing a novel spatiotemporal arrangement and showing that some cells require sequential prey to complete their life cycle.

bioRxiv · Jan 14, 2019Microbiology