Author

T. Cookis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. Mattos· 2 shared E. Nogales· 2 shared P. V. Sauer· 2 shared A. Lydecker· 1 shared A. Singhal· 1 shared D. P. Donnelly· 1 shared E. Pavlenko· 1 shared H. Guterres· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

C. Mattos

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4 papers

Recent·Most cited

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications

T. Cookis, A. Lydecker, P. V. Sauer, V. Kasinath, E. Nogales

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.

bioRxiv · Feb 9, 2024Biochemistry

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

Crystal structure reveals the full Ras:Raf interface and advances mechanistic understanding of Raf activation

T. Cookis, C. Mattos

The paper presents the crystal structure of the HRas/CRaf-RBD_CRD complex and proposes a model for Ras-mediated Raf activation through structural and simulation analysis.

Biomolecules · Jul 7, 2021Peer-reviewedBiophysics

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics