Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection
K. Doyon-Laliberte, M. Aranguren, M. Byrns, J. Chagnon-Choquet, M. Paniconi, J.-P. Routy, C. Tremblay, M.-C. Quintal, N. Brassard, D. E. Kaufmann, J. Poudrier, M. Roger
This study shows that excess BAFF reduces Breg function and NR4A expression in MZp B-cells from HIV-infected individuals, which may impair immune surveillance.
bioRxiv · Aug 15, 2022Immunology