Author

C. Tremblay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Cell Biology· 2 Microbiology· 2 Physiology· 2 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 14 Research Focus:cell type annotation· 13 Approach:experimental assay· 13 Research Focus:differential expression· 8 Research Focus:host-pathogen & immune response· 7 Assay:bulk RNA-seq· 6 Assay:flow cytometry· 5 Assay:proteomics· 5

Frequent Co-Authors

D. E. Kaufmann· 9 shared A. Finzi· 7 shared N. Brassard· 7 shared V. Martel-Laferriere· 7 shared C. Morrisseau· 6 shared G. Goyette· 6 shared L. Gokool· 6 shared C. Bourassa· 5 shared

Activity by Year

2020-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersImmunology

D. E. Kaufmann

Mutual co-authors in cluster

Author profile →

17 papers

Recent·Most cited

A Blood Immunological Signature of Subclinical Coronary Artery Atherosclerosis in People Living with HIV-1 Receiving Antiretroviral Therapy

T. R. Wiche Salinas, Y. Zhang, A. Gosselin, N. Fonseca Do Rosario, M. El-Far, A. Filali-Mouhim, J.-P. Routy, C. Chartrand-Lefebvre, A. L. Landay, M. Durand, C. Tremblay, P. Ancuta

This study identifies immunological markers associated with subclinical coronary artery atherosclerosis in HIV+ individuals on ART, finding reduced Th17/Treg ratios and increased non-classical monocyte frequencies correlate with atherosclerosis burden.

bioRxiv · Dec 15, 2023 · PreprintImmunology

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type alpha-synuclein pathology

S. E. Mastenbroek, J. W. Vogel, L. E. Collij, G. E. Serrano, C. Tremblay, A. L. Young, R. A. Arce, H. A. Shill, E. D. Driver-Dunckley, S. H. Mehta, C. M. Belden, A. Atri, P. Choudhury, F. Barkhof, C. H. Adler, , O. Hansson

The paper models disease progression in Lewy body disorders using neuropathological data, identifying three distinct trajectories of alpha-synuclein pathology with different clinical associations.

bioRxiv · Dec 5, 2023Pathology

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile

G. Sannier, A. Nicolas, M. Dube, L. Marchitto, M. Nayrac, O. Tastet, A. Tauzin, R. Lima-Barbosa, M. Laporte, R. Cloutier, A. S. Flores, M. Boutin, S. Y. Gong, M. Benlarbi, S. Ding, , D. E. Kaufmann

bioRxiv · Sep 5, 2022Immunology

Subclinical Atherosclerosis is Associated with Discrepancies in BAFF and APRIL Levels and Altered Breg Potential of Precursor-like Marginal Zone B-Cells in HIV Treated Individuals

M. Naegele Aranguren, K. Doyon-Laliberte, M. El-Far, C. Chartrand-Lefebvre, J.-P. Routy, J.-G. Baril, B. Trottier, C. Tremblay, M. Durand, J. Poudrier, M. Roger

The paper investigates the association between BAFF and APRIL levels and subclinical atherosclerosis in HIV-treated individuals, finding elevated BAFF correlates with CVD risk factors while APRIL shows inverse correlations.

bioRxiv · Aug 26, 2022Immunology

Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection

K. Doyon-Laliberte, M. Aranguren, M. Byrns, J. Chagnon-Choquet, M. Paniconi, J.-P. Routy, C. Tremblay, M.-C. Quintal, N. Brassard, D. E. Kaufmann, J. Poudrier, M. Roger

This study shows that excess BAFF reduces Breg function and NR4A expression in MZp B-cells from HIV-infected individuals, which may impair immune surveillance.

bioRxiv · Aug 15, 2022Immunology

A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity

A. Nicolas, G. Sannier, M. Dube, M. Nayrac, M. M. Painter, R. R. Goel, M. Laporte, H. R. Medjahed, J. Williams, N. Brassard, J. Niessl, L. Gokool, C. Morrisseau, P. Arlotto, C. Tremblay, , D. E. Kaufmann

This study shows that a longer interval between SARS-CoV-2 mRNA vaccine doses enhances B cell responses but has minimal impact on T cell immunity.

bioRxiv · Aug 3, 2022 · PreprintImmunology

Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

A.-L. Castell, M. Ethier, G. Fergusson, C. Tremblay, C. Goubault, M. Baltz, D. Dal Soglio, J. Ghislain, V. Poitout

This study shows that puberty increases beta-cell proliferation via GH/serotonin signaling, and metabolic stress during puberty affects glucose homeostasis in adulthood.

bioRxiv · Apr 6, 2022Physiology

SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

D. Chatterjee, A. Tauzin, L. Marchitto, S. Y. Gong, M. Boutin, C. Bourassa, G. Beaudoin-Bussieres, Y. Bo, S. Ding, A. Laumaea, D. Vezina, J. Perreault, L. Gokool, C. Morrisseau, P. Arlotto, , A. Finzi

This study evaluates how plasma from individuals with a 16-week interval between BNT162b2 mRNA vaccine doses recognizes and neutralizes the Omicron Spike compared to other variants.

bioRxiv · Dec 21, 2021Microbiology

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

M. Nayrac, M. Dube, G. Sannier, A. Nicolas, L. Marchitto, O. Tastet, A. Tauzin, N. Brassard, G. Beaudoin-Bussieres, D. Vezina, S. Y. Gong, M. Benlarbi, R. Gasser, A. Laumaea, C. Bourassa, , D. E. Kaufmann

The paper examines B and T cell immunity responses to a 16-week interval BNT162b2 vaccine regimen, finding robust immune memory and functional associations between immune components.

bioRxiv · Dec 18, 2021Immunology

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

E. Brunet-Ratnasingham, A. Morou, M. Dube, J. Niessl, A. E. Baxter, O. Tastet, N. Brassard, G. Ortega-Delgado, R. Charlebois, G. J. Freeman, C. Tremblay, J.-P. Routy, D. E. Kaufmann

bioRxiv · Sep 23, 2021Immunology

Covid-19 vaccine immunogenicity in people living with HIV-1

L. Nault, L. Marchitto, G. Goyette, D. Tremblay-Sher, C. Fortin, V. Martel-Laferriere, B. Trottier, J. Richard, M. Durand, D. E. Kaufmann, A. Finzi, C. Tremblay

This study evaluates mRNA vaccine immunogenicity in HIV-positive individuals, finding similar anti-RBD IgG responses to controls in those with CD4 counts >250 cells/mm3, but significantly lower responses in those with <250 cells/mm3.

bioRxiv · Aug 13, 2021Immunology

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses

A. Tauzin, M. Nayrac, M. Benlarbi, S. Y. Gong, R. Gasser, G. Beaudoin-Bussieres, N. Brassard, A. Laumaea, D. Vezina, J. Prevost, S. P. Anand, C. Bourassa, G. Gendron-Lepage, H. Medjahed, G. Goyette, , A. Finzi

This study shows a single dose of the BNT162b2 mRNA vaccine elicits strong antibody and T cell responses, including Fc-mediated effector functions, and boosts pre-existing immunity in previously infected individuals.

bioRxiv · Mar 18, 2021 · PreprintImmunology

Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

S. P. Anand, J. Prevost, M. Nayrac, G. Beaudoin-Bussieres, M. Benlarbi, R. Gasser, N. Brassard, A. Laumaea, S. Y. Gong, C. Bourassa, E. Brunet-Ratnasingham, H. Medjahed, G. Gendron-Lepage, G. Goyette, L. Gokool, , A. Finzi

This study tracks humoral immune responses in convalescent individuals up to 8 months post-SARS-CoV-2 infection, showing that IgG+ memory B cells persist while plasma antibody levels decline.

bioRxiv · Jan 25, 2021Microbiology

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

H. Maachi, J. Ghislain, C. Tremblay, V. Poitout

The paper investigates beta-cell mitogen efficacy in human islets, finding that harmine and HB-EGF stimulate beta-cell proliferation, while glucose effects vary by assay and donor.

bioRxiv · Oct 28, 2020Cell Biology

Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice

M. L. Croze, A. Guillaume, M. Ethier, G. Fergusson, C. Tremblay, S. A. Campbell, H. Maachi, J. Ghislain, V. Poitout

This study shows that deleting both FFAR1 and FFAR4 in mice only slightly affects glucose homeostasis, with minor changes in fasting glucose and glucose tolerance.

bioRxiv · Aug 4, 2020Physiology

Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

M. L. Croze, M. Flisher, A. Guillaume, C. Tremblay, G. M. Noguchi, S. Granziera, K. Vivot, V. C. Castillo, S. A. Campbell, J. Ghislain, M. O. Huising, V. Poitout

This study shows that GPR120 activation in delta cells inhibits somatostatin release, thereby enhancing insulin and glucagon secretion in mice.

bioRxiv · Jul 17, 2020Cell Biology

Repurposing beta3-adrenergic receptor agonists for Alzheimer's disease: Beneficial effects on recognition memory and amyloid pathology in a mouse model.

M. Tournissac, T.-M. Vu, N. Vrabic, C. Hozer, C. Tremblay, K. Melancon, E. Planel, F. Pifferi, F. Calon

This study shows that β3AR agonists improve recognition memory and reduce insoluble Aβ42/Aβ40 ratio in 3xTg-AD mice.

bioRxiv · May 25, 2020Pharmacology & Toxicology