Author

J.-P. Routy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 8 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:clustering· 1

Frequent Co-Authors

P. Ancuta· 5 shared C. Tremblay· 4 shared T. R. Wiche Salinas· 4 shared Y. Zhang· 3 shared A. Gosselin· 2 shared C. Chartrand-Lefebvre· 2 shared D. Chatterjee· 2 shared D. E. Kaufmann· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersImmunology

P. Ancuta

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 15, 2023

A Blood Immunological Signature of Subclinical Coronary Artery Atherosclerosis in People Living with HIV-1 Receiving Antiretroviral Therapy

T. R. Wiche Salinas, Y. Zhang, A. Gosselin…·P. Ancuta

This study identifies immunological markers associated with subclinical coronary artery atherosclerosis in HIV+ individuals on ART, finding reduced Th17/Treg ratios and increased non-classical monocyte frequencies correlate with atherosclerosis burden.

DOI 10.1101/2023.12.15.571922

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 5, 2023

Retinoic Acid Boosts HIV-1 Replication in Macrophages via CCR5/SAMHD1-Dependent and mTOR-Modulated Mechanisms

J. Dias, A. Cattin, J.-P. Goulet…·P. Ancuta

This study shows retinoic acid enhances R5 HIV-1 replication in macrophages through CCR5/SAMHD1 and mTOR pathways.

DOI 10.1101/2023.10.05.561142

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivOct 17, 2022

Identification of Aryl Hydrocarbon Receptor as a Barrier to HIV-1 Infection and Outgrowth in CD4+ T-Cells

D. Chatterjee, Y. Zhang, T. R. Wiche Salinas…·P. Ancuta

This study identifies AhR as a barrier to HIV-1 infection and outgrowth in Th17-polarized CD4+ T-cells and suggests AhR inhibitors could enhance viral outgrowth in HIV-1 cure strategies.

DOI 10.1016/j.celrep.2023.112634

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivAug 26, 2022

Subclinical Atherosclerosis is Associated with Discrepancies in BAFF and APRIL Levels and Altered Breg Potential of Precursor-like Marginal Zone B-Cells in HIV Treated Individuals

M. Naegele Aranguren, K. Doyon-Laliberte, M. El-Far…·M. Roger

The paper investigates the association between BAFF and APRIL levels and subclinical atherosclerosis in HIV-treated individuals, finding elevated BAFF correlates with CVD risk factors while APRIL shows inverse correlations.

DOI 10.3390/vaccines11010081

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivAug 15, 2022

Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection

K. Doyon-Laliberte, M. Aranguren, M. Byrns…·M. Roger

This study shows that excess BAFF reduces Breg function and NR4A expression in MZp B-cells from HIV-infected individuals, which may impair immune surveillance.

DOI 10.3390/ijms232315142

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivSep 23, 2021

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

E. Brunet-Ratnasingham, A. Morou, M. Dube…·D. E. Kaufmann

DOI 10.1016/j.ebiom.2022.104254

humanflow cytometry

𝕏 PostBluesky

MicrobiologybioRxivMar 27, 2021

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

T. R. Wiche Salinas, Y. Zhang, D. Sarnello…·A. Fassati

This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.

DOI 10.1073/pnas.2105927118

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivMay 5, 2020

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in patients receiving antiretroviral therapy: a study from Provir/Latitude45 project.

p. recordon pinson, c. tumiotto, p. bellecave…·h. fleury

The paper compares HIV-1 proviral DNA sequences in blood and gut-associated lymphoid tissue in ART-treated patients, finding low intra-patient divergence and similar CTL epitope profiles between compartments.

DOI 10.1186/s13099-021-00416-6

humanDNA methylation

𝕏 PostBluesky