CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection
T. W. Foreman, C. E. Nelson, K. D. Kauffman, N. E. Lora, C. L. Vinhaes, D. E. Dorosky, S. W. Sakai, F. Gomez, J. D. Fleegle, M. Parham, S. R. Perera, C. S. Lindestam Arlehamn, A. Sette, Tuberculosis Imaging Program, J. M. Brenchley, , D. L. Barber
This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.
bioRxiv · Dec 17, 2021Immunology