Author

N. E. Lora

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. L. Barber· 4 shared K. D. Kauffman· 4 shared L. E. Via· 4 shared A. Sette· 3 shared A. Sher· 3 shared C. E. Nelson· 3 shared D. E. Dorosky· 3 shared S. Namasivayam· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

D. L. Barber

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

C. E. Nelson, S. Namasivayam, T. W. Foreman, K. D. Kauffman, S. Sakai, D. E. Dorosky, N. E. Lora, NIAID/DIR Tuberculosis Imaging Program, K. Brooks, E. L. Potter, M. Roederer, A. Sher, D. Weiskopf, A. Sette, E. de Wit, , D. L. Barber

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

bioRxiv · Jan 6, 2022Immunology

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

T. W. Foreman, C. E. Nelson, K. D. Kauffman, N. E. Lora, C. L. Vinhaes, D. E. Dorosky, S. W. Sakai, F. Gomez, J. D. Fleegle, M. Parham, S. R. Perera, C. S. Lindestam Arlehamn, A. Sette, Tuberculosis Imaging Program, J. M. Brenchley, , D. L. Barber

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

bioRxiv · Dec 17, 2021Immunology

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

S. Sakai, N. E. Lora, K. D. Kauffman, D. E. Dorosky, S. Oh, S. Namasivayam, F. Gomez, J. D. Fleegle, C. S. Lindestam Arlehamn, A. Sher, G. J. Freeman, L. E. Via, C. E. Barry, D. L. Barber

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

bioRxiv · Jan 29, 2021Immunology

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

K. D. Kauffman, S. Sakai, N. E. Lora, S. Namasivayam, P. J. Baker, O. Kamenyeva, T. W. Foreman, C. E. Nelson, D. Oliveira-de-Souza, C. L. Vinhaes, Z. Yaniv, C. S. Lindestam Arleham, A. Sette, G. J. Freeman, R. Moore, , D. L. Barber

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.

bioRxiv · Aug 5, 2020Immunology