A. Sette

PINK1 is a target of T cell responses in Parkinson's disease

The paper identifies PINK1 as an autoantigen targeted by T cells in Parkinson's disease, with reactivity predominantly observed in male patients.

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans

This study identifies CHIKV-specific CD4+ T cell responses in chronic CHIKVD patients, showing stronger responses and Th17 enrichment compared to resolved infection.

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles.

This study maps human CD4+ T cell responses to Bordetella pertussis across its genome, revealing broad reactivity and similar polarization regardless of vaccination history.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses

This study identifies T cell epitopes and cross-reactivity patterns across common cold coronaviruses, highlighting conservation and limitations in cross-reactivity among subgenera.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

Defining antigen targets to dissect vaccinia virus (VACV) and Monkeypox virus (MPXV)-specific T cell responses in humans

The paper predicts MPXV T cell epitopes using VACV epitope data and identifies immunodominant targets to design peptide pools for detecting cross-reactive T cells in vaccinated individuals.

Profile of Mycobacterium tuberculosis-specific CD4 T cells at the site of disease and blood in pericardial tuberculosis

This study compares Mtb-specific CD4 T cell profiles in pericardial fluid and blood from PCTB patients, finding distinct phenotypes in PCF with no difference in cytokine production.

NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses

This study shows NVX-CoV2373 vaccine induces CD4+ and CD8+ T cell responses, with CD4+ T cells correlating with neutralizing antibody titers.

Unaltered T cell responses to common antigens in individuals with Parkinson's disease

This study compares T cell responses to common antigens in Parkinson's disease patients and healthy controls, finding no significant differences in antigen-specific T cell activation or cytokine production.

Peripheral blood T-cell deficiency and hyperinflammatory monocyte responses associate with MAC lung disease

The paper investigates immune responses in individuals with MAC lung disease, finding reduced T-cell responses and hyperinflammatory monocyte activity.

Humoral and cellular immune memory to four COVID-19 vaccines

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

This study evaluates neutralizing activity against Omicron BA.1 and BA.2 variants elicited by various vaccines and finds that booster doses enhance neutralizing titers and breadth across all vaccine platforms.

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

The paper assesses immunological memory to Common Cold Coronaviruses over three years and finds sustained CD4+ T cell and antibody responses, suggesting stable memory rather than frequent reinfections.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response

The paper analyzes the quality of SARS-CoV-2 specific T-cell response in relation to disease severity, immune memory, and heterologous response, finding distinct patterns in mild and severe infections and immune memory.

SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

Distinguishing COVID-19 infection and vaccination history by T cell reactivity

This study develops a T cell-based method to distinguish between SARS-CoV-2 infection and vaccination by analyzing T cell reactivity to specific epitopes, achieving high classification accuracy across different groups.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs

The paper identifies 235 unique HCMV-specific T cell epitopes, including 41 from recently described novel ORFs, revealing a broader T cell response to HCMV than previously known.

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

The paper analyzes T cell responses to SARS-CoV-2 variants and finds minimal impact on CD4+ and CD8+ T cell reactivity in convalescents and vaccinees.

TCRMatch: Predicting T-cell receptor specificity based on sequence similarity to previously characterized receptors

TCRMatch predicts T-cell receptor specificity by comparing sequence similarity to known epitope-specific receptors in the IEDB.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.