B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models
D. Huang, R. K. Abbott, C. Havenar-Daughton, P. Skog, R. Al-Kolla, B. Groschel, T. Blane, S. Menis, J. T. Tran, T. C. Thinnes, S. A. Volpi, M. Pintea, J. E. Voss, N. Phelps, R. Tingle, , S. Crotty
The paper demonstrates that authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple mouse models, validating germline-targeting vaccine design.
bioRxiv · Feb 24, 2020Immunology