ImmunologybioRxiv
B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models
D. Huang, R. K. Abbott, C. Havenar-Daughton…·S. Crotty
The paper demonstrates that authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple mouse models, validating germline-targeting vaccine design.