Author

M. R. Miranda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 2 Approach:deep learning· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

C. A. Pereira· 4 shared C. Reigada· 4 shared M. Saye· 4 shared E. Valera-Vera· 3 shared F. A. Digirolamo· 2 shared E. A. Valera-Vera· 1 shared F. Di Girolamo· 1 shared F. Galceran· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

C. A. Pereira

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivJun 23, 2020

Capsaicin inhibits arginine kinase and exerts anti-Trypanosoma cruzi activity

E. Valera-Vera, C. Reigada, M. Saye…·C. A. Pereira

This study evaluates capsaicin's effect on TcAK activity and its trypanocidal activity against T. cruzi, finding it more effective than benznidazole.

DOI 10.1093/femsle/fnaa194

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivJun 23, 2020

Trypanocidal activity of the anthocyanidin delphinidin, a non-competitive inhibitor of arginine kinase

E. Valera-Vera, C. Reigada, M. Saye…·C. A. Pereira

The paper demonstrates that delphinidin inhibits TcAK in vitro with non-competitive kinetics and shows trypanocidal activity against T. cruzi.

DOI 10.1080/14786419.2021.1947270

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky

MicrobiologybioRxivNov 4, 2019

Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA-damage responses

C. Reigada, M. Saye, F. Di Girolamo…·M. R. Miranda

This study investigates the role of TcNDPK1 in DNA-damage responses in Trypanosoma cruzi, showing reduced mutation rates and increased resistance to genotoxic stress.

DOI 10.1590/0074-02760200019

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivJun 27, 2019

In silico identification of putative Trypanosoma cruzi enolase inhibitors

E. Valera-Vera, M. Saye, C. Reigada…·C. A. Pereira

The paper identifies potential inhibitors of Trypanosoma cruzi enolase using virtual screening, docking, and dynamics simulations, proposing etidronate as a candidate inhibitor.

DOI 10.1016/j.jmgm.2019.107506

virusproteomics

𝕏 PostBluesky