Author

M. Roberge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Baradaran-Heravi· 3 shared A. D. Balgi· 3 shared C. A. N. Gerak· 2 shared L. P. McIntosh· 2 shared R. B. Sessions· 2 shared A. Balgi· 1 shared A. Jacobson· 1 shared A. Weil· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

A. Baradaran-Heravi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

A. Baradaran-Heravi, C. C. Bauer, I. B. Pickles, S. Hosseini-Farahabadi, A. Balgi, K. Choi, D. M. Linley, D. J. Beech, M. Roberge, R. S. Bon

This study shows that AC1903 suppresses aminoglycoside-induced PTC readthrough by inhibiting multiple TRPC channels, but its mechanism remains unclear.

bioRxiv · Apr 7, 2021 · PreprintPharmacology & Toxicology

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

P. D. Slaine, M. Kleer, B. Duguay, E. S. Pringle, E. Kadijk, S. Ying, A. D. Balgi, M. Roberge, C. McCormick, D. A. Khaperskyy

This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.

bioRxiv · Sep 30, 2020Microbiology

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

C. A. N. Gerak, S. Y. Cho, M. Kolesnikov, M. Okon, M. E. P. Murphy, R. B. Sessions, M. Roberge, L. P. McIntosh

This study characterizes the biophysical properties of the ETV6 PNT domain polymerization interfaces to identify potential drug targets for inhibiting its self-association.

bioRxiv · Aug 21, 2020Biochemistry

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

C. A. N. Gerak, S. M. Zhang, A. D. Balgi, I. J. Sadowski, R. B. Sessions, L. P. McIntosh, M. Roberge

This study develops experimental and computational assays to identify small molecule inhibitors of ETV6 PNT domain polymerization, finding no direct binders but gaining insights for future therapeutic development.

bioRxiv · Aug 20, 2020Biochemistry

Gentamicin B1 is not a minor gentamicin component with major nonsense mutation suppression activity

A. Baradaran-Heravi, D. E. Williams, D. A. Powell, A. D. Balgi, R. J. Andersen, M. Roberge

The paper identifies that a previously reported gentamicin B1 compound was actually G418 and shows that true gentamicin B1 lacks PTC readthrough activity.

bioRxiv · Nov 23, 2018 · PreprintBiochemistry

A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery

M. Y. Ng, H. Zhang, A. Weil, V. Singh, R. M. Jamiolkowski, A. Baradaran-Heravi, M. Roberge, A. Jacobson, W. Friesen, E. Welch, Y. Goldman, B. S. Cooperman

The paper introduces a new in vitro assay to measure direct nonsense suppressor-induced readthrough and identifies two distinct mechanisms among tested suppressors.

bioRxiv · Nov 7, 2018Biochemistry