K. Choi

Explainable machine learning for health disparities: type 2 diabetes in the All of Us research program

This paper uses explainable machine learning to identify and quantify T2D risk factors contributing to health disparities among different racial and ethnic groups in the All of Us research program.

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

Zbtb46 coordinates angiogenesis and immunity to control tumor outcome

This study identifies Zbtb46 as a regulator that coordinates angiogenesis and immunity in tumors, with its downregulation promoting a pro-tumor microenvironment and its restoration improving tumor outcomes.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Interleukin-1α and Leukemia Inhibitory Factor Promote Extramedullary Hematopoiesis

This study identifies IL-1 and LIF as factors promoting EMH by activating splenic niche cells and inducing an inflammatory gene signature in HSPCs.

Chronic inflammation suppresses del(5q)-like MDS HSCs via p53

This study shows chronic inflammation impairs del(5q)-like MDS HSPCs by activating p53, leading to reduced quiescence and disease severity, which may drive p53 mutations in myeloid malignancies.

The inner nuclear membrane protein NEMP1 is required for nuclear envelope openings and enucleation of erythroblasts during erythropoiesis

This study shows NEMP1 is essential for nuclear envelope openings and enucleation in erythroblasts, leading to anemia and splenomegaly in Nemp1 knockout mice.

Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapy

The paper identifies three conserved angio-immune subtypes in cancer microenvironments and shows that high immune activity with low angiogenesis correlates with better response to immune checkpoint blockade therapy.

HEAT SHOCK FACTOR BINDING PROTEIN limits meiotic crossovers by repressing HEI10 transcription

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

This study shows that AC1903 suppresses aminoglycoside-induced PTC readthrough by inhibiting multiple TRPC channels, but its mechanism remains unclear.

Biochemical and Biophysical Characterization of the dsDNA packaging motor from the Lactococcus lactis bacteriophage asccphi28

The paper characterizes the ATPase motor of Lactococcus lactis phage asccphi28, showing it forms functional rings in solution and has ATPase activity comparable to capsid-bound motors.

Prostate Epithelial Genes Define Docetaxel-Sensitive Prostate Cancer Molecular Subtype

The paper identifies four molecular subtypes of prostate adenocarcinoma using transcriptomic data and links subtype B to docetaxel sensitivity and PSA/PAP ratio as a predictive biomarker.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

DeepTetrad: high-throughput analysis of meiotic tetrads by deep learning in plants

DeepTetrad uses deep learning to analyze pollen tetrads and measure crossover frequency and interference in Arabidopsis plants.

Arp2/3 complex-driven spatial patterning of the B cell receptor (BCR) enhances immune synapse formation, BCR signaling, and cell activation

The paper shows that Arp2/3 complex-driven spatial reorganization of BCR microclusters enhances immune synapse formation, BCR signaling, and B cell activation in response to membrane-bound antigens.

Single-cell Map of Diverse Immune Phenotypes Driven by the Tumor Microenvironment

The paper maps immune cell phenotypes in breast cancer using single-cell RNA-seq and identifies continuous tumor-specific expansions driven by environmental cues.