Author

A. Jacobson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 2 Immunology· 2 Plant Biology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:plant (other)· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

G. G. Kennedy· 2 shared L. Hanley-Bowdoin· 2 shared Y. Wang· 2 shared A. A. Khan· 1 shared A. A. Korostelev· 1 shared A. A. McLaughlin· 1 shared A. B. Loveland· 1 shared A. Baradaran-Heravi· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersPlant Biology

G. G. Kennedy

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Author profile →

10 papers

Recent·Most cited

Structural mechanism of angiogenin activation by the ribosome

A. B. Loveland, C. S. Koh, R. Ganesan, A. Jacobson, A. A. Korostelev

This study identifies the ribosome as the activator of angiogenin, revealing how it enhances tRNA cleavage efficiency and ensures substrate specificity through structural rearrangements.

bioRxiv · Dec 11, 2023Biochemistry

Vector acquisition and co-inoculation of two plant viruses influences transmission, infection, and replication in new hosts

A. A. McLaughlin, L. Hanley-Bowdoin, G. G. Kennedy, A. Jacobson

This study examines how the acquisition and transmission of two plant viruses by whiteflies affects their spread and replication in new hosts.

bioRxiv · Aug 27, 2022Plant Biology

Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

J. Spring, S. Lara, A. A. Khan, K. O'Grady, J. Wilks, S. Gurbuxani, S. Erickson, M. Fischbach, A. Jacobson, A. Chervonsky, T. Golovkina

This study shows that gut commensal bacteria enhance MuLV-induced leukemia by suppressing the adaptive immune response through upregulation of immune regulators.

bioRxiv · Feb 2, 2022Microbiology

Affinity sedimentation and magnetic separation with plant-made immunosorbent nanoparticles for therapeutic protein purification

M. J. McNulty, A. Schwartz, J. Delzio, K. Karuppanan, A. Jacobson, O. Hart, A. Dandekar, A. Giritch, S. Nandi, Y. Gleba, K. A. McDonald

This paper develops plant-made immunosorbent nanoparticles for therapeutic protein purification, demonstrating enhanced binding capacity and introducing magnetic separation to improve efficiency.

bioRxiv · Nov 5, 2021 · PreprintBioengineering

Population diversity of cassava mosaic begomoviruses increases over the course of serial vegetative propagation

C. D. Aimone, E. Lavington, J. S. Hoyer, D. O. Deppong, L. Mickelson-Young, A. Jacobson, G. G. Kennedy, I. Carbone, L. Hanley-Bowdoin, S. Duffy

This study shows that vegetative propagation increases viral diversity in cassava mosaic begomoviruses over time, while temperature and satellite DNA have minimal impact.

bioRxiv · Mar 22, 2021Plant Biology

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

J. Luban, R. Sattler, E. Muhlberger, J. D. Graci, L. Cao, M. Weetall, C. Trotta, J. M. Colacino, S. Bavari, C. Strambio-De-Castillia, E. L. Suder, Y. Wang, V. Soloveva, K. Cintron-Lue, N. A. Naryshkin, , S. Peltz

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

bioRxiv · Aug 5, 2020Immunology

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

Y. WU, Y. Liu, Z. Huang, X. Wang, Z. Jin, J. Li, P. Limsakul, L. Zhu, M. Allen, Y. Pan, R. Bussell, A. Jacobson, T. Liu, S. Chien, Y. Wang

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

bioRxiv · Feb 18, 2020Bioengineering

MicroRNA miR-7 regulates synthesis and secretion of insulin-like peptides

P. Agbu, J. J. Cassidy, J. Braverman, A. Jacobson, R. W. Carthew

This study shows miR-7 regulates insulin-like peptides by inhibiting production and secretion through targeting CPA, with conserved effects in mammals.

bioRxiv · Oct 3, 2019Physiology

Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cells

N. Y. Lai, M. A. Musser, F. A. Pinho-Ribeiro, P. Baral, P. Ma, D. E. Potts, Z. Chen, D. Paik, S. Soualhi, H. Shi, A. Misra, K. Goldstein, K. N. Sivanathan, A. Jacobson, A. Wallrapp, , I. M. Chiu

This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.

bioRxiv · Mar 21, 2019 · PreprintImmunology

A new in vitro assay measuring direct interaction of nonsense suppressors with the eukaryotic protein synthesis machinery

M. Y. Ng, H. Zhang, A. Weil, V. Singh, R. M. Jamiolkowski, A. Baradaran-Heravi, M. Roberge, A. Jacobson, W. Friesen, E. Welch, Y. Goldman, B. S. Cooperman

The paper introduces a new in vitro assay to measure direct nonsense suppressor-induced readthrough and identifies two distinct mechanisms among tested suppressors.

bioRxiv · Nov 7, 2018Biochemistry