The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors
M. Rouanet, H. Lulka, P. Garcin, M. Sramek, D. Pagan, C. Valle, E. Sarot, V. Pancaldi, F. Lopez, L. Buscail, P. Cordelier
This study shows that TLR7 ligands inhibit pancreatic cancer cell growth in vitro but promote tumor growth in immunocompetent mice due to increased tumor-promoting macrophages.
bioRxiv · Mar 5, 2020Cancer Biology