Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features
S. R. Rao, C. Verrill, L. Cerundolo, N. K. Alham, Z. Kaya, M. O'Hanlon, A. Hayes, A. Lambert, M. James, I. D. C. Tullis, J. Niederer, S. Lovell, A. Omer, F. Lopez, T. Leslie, , F. C. Hamdy
This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.
bioRxiv · Feb 27, 2023Cancer Biology