Author

K. Stouffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:imaging· 4 Research Focus:cell type annotation· 3 Research Focus:spatial domain detection· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

D. J. Tward· 3 shared M. Witter· 3 shared A. Bergman· 2 shared A. Casadevall· 2 shared C. Chen· 2 shared E. Xu· 2 shared J. Troncoso· 2 shared M. Albert· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioengineering

D. J. Tward

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Author profile →

5 papers

Recent·Most cited

Chaotic signatures in host-microbe interactions

Y. Sella, N. A. Broderick, K. Stouffer, D. L. McEwan, F. M. Ausubel, A. Casadevall, A. Bergman

This study investigates whether time-to-death datasets can reveal chaotic signatures in host-microbe interactions using simulated and experimental data from C. elegans and Drosophila infected with Pseudomonas species.

bioRxiv · Dec 14, 2022 · PreprintMicrobiology

Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimer's Disease

K. Stouffer, C. Chen, S. Kulason, E. Xu, M. Witter, C. Ceritoglu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. I. Miller

This study measures amygdala and ERC atrophy rates in preclinical Alzheimer's disease using MRI and reconstructs 3D tau pathology distributions, finding amygdala atrophy comparable to ERC and suggesting it as a potential biomarker.

bioRxiv · Jun 6, 2022 · PreprintBioengineering

Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

K. Stouffer, M. Witter, D. J. Tward, M. I. Miller

This paper introduces Projective LDDMM, a method mapping dense MRI atlases to sparse histological measurements, with applications in Alzheimer's biomarker development.

bioRxiv · Apr 22, 2022 · PreprintBioengineering

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

K. Stouffer, M. Witter, C. Chen, E. Xu, M. Albert, S. Mori, J. Troncoso, D. J. Tward, M. Miller

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

bioRxiv · Mar 16, 2022 · PreprintBioengineering

Macrophages utilize a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification

Q. Dragotakes, K. Stouffer, M. S. Fu, Y. Sella, C. Youn, I. Yoon, C. M. Leon-Rodriguez, J. B. Freij, A. Bergman, A. Casadevall

The paper shows macrophages use a bet-hedging strategy by stochastically acidifying phagolysosomes to reduce variation in antimicrobial effectiveness.

bioRxiv · Mar 11, 2020Microbiology