Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases
J. Chrustowicz, D. Sherpa, J. Teyra, M. S. Loke, G. Popowicz, J. Basquin, M. Sattler, J. R. Prabu, S. S. Sidhu, B. A. Schulman
The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.
bioRxiv · Sep 3, 2021Biochemistry