Author

B. A. Schulman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 7 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 7 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Research Focus:protein folding & dynamics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:yeast· 3

Frequent Co-Authors

J. R. Prabu· 5 shared R. Vollrath· 3 shared S. S. Sidhu· 3 shared D. Sherpa· 2 shared E. A. Goodall· 2 shared F. Adolf· 2 shared F. Wilfling· 2 shared I. R. Smith· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersBiochemistry

J. R. Prabu

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Author profile →

10 papers

Recent·Most cited

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

F. Adolf, J. Du, E. A. Goodall, R. M. Walsh, S. rawson, S. von Gronaua, J. W. Harper, J. Hanna, B. A. Schulman

The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.

bioRxiv · Jan 27, 2024Biochemistry

Combinatorial selective ER-phagy remodels the ER during neurogenesis

M. J. Hoyer, C. Capitanio, I. R. Smith, J. C. Paoli, A. Bieber, Y. Jiang, J. A. Paulo, M. A. Gonzalez-Lozano, W. Baumeister, F. Wilfling, B. A. Schulman, W. Harper

The paper quantifies ER proteome remodeling during neurogenesis using ER-phagy receptors and identifies receptor-specific ER protein clearance mechanisms.

bioRxiv · Jun 26, 2023Cell Biology

Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

L. A. Hehl, D. Horn-Ghetko, J. R. Prabu, R. Vollrath, D. T. Vu, D. A. Perez Berrocal, M. P. C. Mulder, G. J. van der Heden van Noort, B. A. Schulman

This study uses cryo-EM to reveal the structural mechanism of K48-linked ubiquitin chain formation by the HECT E3 ligase UBR5, showing how it orchestrates ubiquitin transfer through conformational changes.

bioRxiv · Jun 6, 2023Biochemistry

Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

I. Wallace, K. Baek, J. R. Prabu, R. Vollrath, S. von Gronau, B. A. Schulman, K. N. Swatek

This study presents a cryo-EM structure of the UBE1L-UBE2L6 complex bound to ISG15, revealing mechanisms of ISG15 recognition and conjugation pathway specificity.

bioRxiv · Apr 6, 2023Biochemistry

Activity-based profiling of cullin-RING ligase networks by conformation-specific probes

L. T. Henneberg, J. Singh, D. M. Duda, K. Baek, D. Yanishevski, P. J. Murray, M. Mann, S. S. Sidhu, B. A. Schulman

The paper develops conformation-specific probes to profile activated cullin-RING ligase networks, revealing differential regulation across cell types and activation pathways.

bioRxiv · Jan 14, 2023 · PreprintBiochemistry

PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems

F. Kraus, E. A. Goodall, I. R. Smith, Y. Jiang, J. C. Paoli, F. Adolf, J. Zhang, J. A. Paulo, B. A. Schulman, J. W. Harper

This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.

bioRxiv · Nov 2, 2022Cell Biology

Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases

J. Chrustowicz, D. Sherpa, J. Teyra, M. S. Loke, G. Popowicz, J. Basquin, M. Sattler, J. R. Prabu, S. S. Sidhu, B. A. Schulman

The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.

bioRxiv · Sep 3, 2021Biochemistry

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

D. Sherpa, J. Chrustowicz, S. Qiao, C. R. Langlois, L. A. Hehl, K. V. Gottemukkala, F. M. Hansen, O. Karayel, S. von Gronau, J. R. Prabu, M. Mann, A. F. Alpi, B. A. Schulman

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

bioRxiv · Apr 7, 2021Biochemistry

A selective autophagy pathway for phase separated endocytic protein deposits

F. Wilfling, C.-W. Lee, P. Erdmann, Y. Zheng, S. Jentsch, B. Pfander, B. A. Schulman, W. Baumeister

The paper identifies Ede1 as a selective autophagy receptor for endocytic protein condensates, showing its role in phase separation and autophagic degradation.

bioRxiv · May 26, 2020Cell Biology

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

E. R. Watson, C. R. R. Grace, W. Zhang, D. J. Miller, I. F. Davidson, J. R. Prabu, S. Yu, D. L. Bolhuis, E. T. Kulko, R. Vollrath, D. Haselbach, H. Stark, J.-M. Peters, N. G. Brown, S. S. Sidhu, B. A. Schulman

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.

bioRxiv · Jun 12, 2019 · PreprintBiochemistry