Author

J. Chrustowicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Organism:yeast· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Sherpa· 4 shared M. Mann· 3 shared O. Karayel· 3 shared A. F. Alpi· 2 shared B. A. Schulman· 2 shared B. Schulman· 2 shared C. R. Langlois· 2 shared J. R. Prabu· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCell Biology

D. Sherpa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

D. Sherpa, J. Mueller, O. Karayel, J. Chrustowicz, P. Xu, K. V. Gottemukkala, C. Baumann, A. Gross, O. Czarnezki, W. Zhang, J. Gu, J. Nilvebrant, M. J. Weiss, S. Sidhu, P. J. Murray, , A. F. Alpi

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

bioRxiv · Jan 18, 2022 · PreprintCell Biology

Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases

J. Chrustowicz, D. Sherpa, J. Teyra, M. S. Loke, G. Popowicz, J. Basquin, M. Sattler, J. R. Prabu, S. S. Sidhu, B. A. Schulman

The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.

bioRxiv · Sep 3, 2021Biochemistry

A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters

C. R. Langlois, V. Beier, O. Karayel, J. Chrustowicz, D. Sherpa, M. Mann, B. Schulman

The paper shows that the GID E3 ligase system regulates plasma membrane transporters through a stress-specific substrate receptor, Gid10, and ubiquitinates Art2.

bioRxiv · Sep 2, 2021Cell Biology

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

D. Sherpa, J. Chrustowicz, S. Qiao, C. R. Langlois, L. A. Hehl, K. V. Gottemukkala, F. M. Hansen, O. Karayel, S. von Gronau, J. R. Prabu, M. Mann, A. F. Alpi, B. A. Schulman

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

bioRxiv · Apr 7, 2021Biochemistry

MicroED Structures of HIV-1 Gag CTD-SP1 Reveal Binding Interactions with the Maturation Inhibitor Bevirimat

M. D. Purdy, D. Shi, J. Chrustowicz, J. Hattne, T. Gonen, M. Yeager

The paper uses MicroED to determine the structure of HIV-1 Gag CTD-SP1 with bevirimat, revealing binding interactions that inform drug discovery.

bioRxiv · Dec 30, 2017Biophysics