J. Basquin

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by minor groove anchor competition

The paper determines the structure of NR5A2 bound to a nucleosome, revealing how it competes with the minor groove anchor to destabilize nucleosomes and facilitate gene expression during reprogramming.

Fluorescent Sensors for Imaging Interstitial Calcium

This paper introduces GreenT-ECs, genetically encoded calcium sensors designed for high spatio-temporal resolution imaging of interstitial calcium in live tissues.

Structures of Arabidopsis thaliana MDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors

A. thaliana MDLs and human MIF interact to synergistically activate CXCR2 and CXCR4 signaling.

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism

The paper reports the crystal structure of an ADH enzyme that catalyzes a non-canonical 1,4 reduction, providing insights into how plant ADHs diversify their catalytic functions.

Multifaceted N-degron recognition and ubiquitylation by GID/CTLH E3 ligases

The paper identifies novel N-terminal motifs recognized by Gid4 and Gid10 E3 ligases and shows how structural flexibility and substrate context influence ubiquitylation efficiency.

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans

The paper determines the structure of the PETISCO complex in C. elegans and elucidates its role in piRNA biogenesis and early embryogenesis.

Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

The paper shows Nse5/6 inhibits Smc5/6 ATPase activity, modulating DNA substrate selection in yeast.

A rod conformation of the Pyrococcus furiosus Rad50 coiled coil

The paper presents a crystal structure of an alternate conformation of the Pyrococcus furiosus Rad50 coiled coil, showing co-aligned coils instead of the previously reported anti-parallel arrangement.