M. S. Wolfe

Molecular Dynamics Activation of γ-Secretase for Cleavage of Notch1 Substrate

This study uses molecular dynamics simulations and mass spectrometry to model how γ-secretase cleaves Notch1, revealing structural dynamics and substrate interactions.

Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production

The paper synthesizes and tests aryl aminothiazole γ-secretase modulators, finding that structural changes alter Aβ peptide production profiles and stimulate carboxypeptidase trimming.

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction

The paper designs TMD mimetics to trap different stages of γ-secretase-substrate interactions, identifying inhibitors for endoproteolysis, TMD unwinding, and lateral gating.

Mechanism of Tripeptide Trimming by γ-Secretase

This study investigates the mechanism of tripeptide trimming by γ-secretase using biochemical experiments and simulations, revealing structural changes required for the process and how mutations affect it.

Mechanisms of γ-Secretase Activation and Substrate Processing

This study uses simulations and experiments to elucidate γ-secretase activation and substrate processing mechanisms, revealing how mutations affect cleavage sites and enzyme function.