BiophysicsbioRxiv
Molecular Dynamics Activation of γ-Secretase for Cleavage of Notch1 Substrate
H. N. Do, S. R. Malvankar, M. S. Wolfe, Y. Miao
This study uses molecular dynamics simulations and mass spectrometry to model how γ-secretase cleaves Notch1, revealing structural dynamics and substrate interactions.
DOI 10.1021/acschemneuro.3c00594