S. Devkota

The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice.

This study shows that gut microbiota depletion reduces cardiovascular inflammation in a mouse model of Kawasaki disease, and specific bacteria or their metabolites can alleviate vasculitis by improving gut barrier function.

Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

This study identifies aryl-lactates as bioactive metabolites in fermented foods and shows their production can be enhanced to boost AhR receptor activity.

Mechanical Properties of Native and Decellularized Reproductive Tissues: Insights for Tissue Engineering Strategies

This study examines mechanical properties and porosity of native and decellularized bovine reproductive tissues across the estrous cycle to inform tissue engineering strategies.

Systemic IgG repertoire as a biomarker for translocating gut microbiota members

The paper identifies gut microbiota members that translocate across the gastrointestinal barrier using systemic IgG as a biomarker, finding elevated IgG responses in IBD patients against specific taxa.

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction

The paper designs TMD mimetics to trap different stages of γ-secretase-substrate interactions, identifying inhibitors for endoproteolysis, TMD unwinding, and lateral gating.

Mechanism of Tripeptide Trimming by γ-Secretase

This study investigates the mechanism of tripeptide trimming by γ-secretase using biochemical experiments and simulations, revealing structural changes required for the process and how mutations affect it.

Seasonal Abundance and Spatial Pattern of Distribution of Liriomyza trifolii (Diptera: Agromyzidae) and Its Parasitoid on Bean and Squash in South Florida.

The paper studies seasonal abundance and spatial distribution of Liriomyza trifolii and its parasitoids on bean and squash in South Florida over four growing periods.

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice

This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.

Mechanisms of γ-Secretase Activation and Substrate Processing

This study uses simulations and experiments to elucidate γ-secretase activation and substrate processing mechanisms, revealing how mutations affect cleavage sites and enzyme function.