Author

M. Sawicka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein structure prediction· 4 Assay:cryo-EM· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. Dutzler· 4 shared D. Deneka· 2 shared A. Dittmann· 1 shared C. Albrecht· 1 shared C. Alvadia· 1 shared C. Breen· 1 shared D. N. Tippett· 1 shared I. Querques· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

R. Dutzler

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Author profile →

5 papers

Recent·Most cited

Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

D. N. Tippett, C. Breen, S. J. Butler, M. Sawicka, R. Dutzler

The paper determines the structure of human SLC26A6 and identifies it as a coupled chloride-bicarbonate exchanger, revealing structural differences that explain its anion selectivity and coupling mechanism compared to SLC26A9.

bioRxiv · Mar 6, 2023Biophysics

Structure of a volume-regulated heteromeric LRRC8A/C channel

S. Rutz, D. Deneka, A. Dittmann, M. Sawicka, R. Dutzler

This study determines the structure of a heteromeric LRRC8A/C channel, revealing its unique organization and activation mechanism.

bioRxiv · Aug 3, 2022Biochemistry

Mechanism of R-loop formation and conformational activation of Cas9

M. Pacesa, L. Loeff, I. Querques, L. M. Muckenfuss, M. Sawicka, M. Jinek

This study reports cryo-EM structures of Cas9 during R-loop formation, revealing conformational changes that activate the nuclease domain and improve understanding of its specificity.

bioRxiv · Sep 16, 2021Biochemistry

Cryo-EM structures of the Caspase activated protein XKR9 involved in apoptotic lipid scrambling

R. Dutzler, M. S. Straub, C. Alvadia, M. Sawicka

The paper presents cryo-EM structures of XKR9, a lipid scramblase, showing its monomeric architecture and activation mechanism via caspase cleavage.

bioRxiv · May 3, 2021Biophysics

Cryo-EM structures and functional properties of CALHM channels of the human placenta

K. Drozdzyk, M. Sawicka, M.-I. Bahamonde-Santos, Z. Jonas, D. Deneka, C. Albrecht, R. Dutzler

The paper investigates CALHM channels in the human placenta, identifying their expression patterns and structural differences, and links these to functional properties and lipid distribution.

bioRxiv · Feb 11, 2020Biophysics