Author

L. M. Muckenfuss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Jinek· 2 shared A. C. Migenda Herranz· 1 shared F. M. Boneberg· 1 shared I. Querques· 1 shared L. Loeff· 1 shared M. Clerici· 1 shared M. Pacesa· 1 shared M. Sawicka· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

M. Jinek

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2 papers

Recent·Most cited

BiochemistryNaturePeer-reviewedAug 24, 2022

Mechanism of R-loop formation and conformational activation of Cas9

M. Pacesa, L. Loeff, I. Querques…·M. Jinek

This study reports cryo-EM structures of Cas9 during R-loop formation, revealing conformational changes that activate the nuclease domain and improve understanding of its specificity.

DOI 10.1038/s41586-022-05114-0

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivMay 31, 2022

Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis

L. M. Muckenfuss, A. C. Migenda Herranz, F. M. Boneberg…·M. Jinek

This study reports two crystal structures of human Fip1 interacting with CPSF30 and CstF77, showing its role in mRNA 3' end processing by scaffolding and regulating PAP recruitment.

DOI 10.7554/elife.80332

humanstructural biology

𝕏 PostBluesky