Author

I. Querques

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

M. Jinek· 3 shared C. Chanez· 2 shared M. Schmitz· 2 shared S. Oberli· 2 shared L. Loeff· 1 shared L. M. Muckenfuss· 1 shared M. Pacesa· 1 shared M. Sawicka· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

M. Jinek

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons

M. Schmitz, I. Querques, S. Oberli, C. Chanez, M. Jinek

This study presents a cryo-EM structure of a CRISPR-associated transposon complex, revealing RNA-mediated assembly mechanisms and the role of ribosomal protein S15 in transposition.

bioRxiv · Jun 17, 2022 · PreprintBiochemistry

Mechanism of R-loop formation and conformational activation of Cas9

M. Pacesa, L. Loeff, I. Querques, L. M. Muckenfuss, M. Sawicka, M. Jinek

This study reports cryo-EM structures of Cas9 during R-loop formation, revealing conformational changes that activate the nuclease domain and improve understanding of its specificity.

bioRxiv · Sep 16, 2021Biochemistry

Molecular mechanism of target site selection and remodeling by type V CRISPR-associated transposons

I. Querques, M. Schmitz, S. Oberli, C. Chanez, M. Jinek

This study elucidates the molecular mechanism of RNA-directed DNA transposition by type V-K CRISPR-associated transposons using cryo-EM structures and biochemical assays.

bioRxiv · Jul 6, 2021 · PreprintBiochemistry