Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations
H. Ali, I. Puccio, A. Akarca, R. Bob, S. Pomplun, W. K. Wong, R. Gupta, M. Sekhar, J. Lambert, H. Al-Masri, H. Stein, T. Marafioti
The paper validates the use of CAL2 antibody for detecting CALR mutations in MPNs through immunohistochemistry and confirms its specificity to mutated CALR in ET and MDS/MPN.
bioRxiv · Dec 22, 2019Pathology