P. Kaur

A conjugative plasmid exploits flagella rotation as a cue to facilitate its transfer

The paper shows that the plasmid pLS20 uses flagella rotation to trigger conjugation in Gram-positive bacteria, enabling DNA transfer in liquid environments.

Using an agent based model to inform sampling design for animal social network analysis

The paper uses an agent-based model to evaluate how sampling strategies affect the accuracy of social network metrics in animal studies, identifying optimal trade-offs between coverage, frequency, and duration.

aniSNA : An R package to assess bias and uncertainty in social networks obtained from animals sampled via direct observations or satellite telemetry

aniSNA assesses bias and uncertainty in animal social networks from telemetry data, enabling reliable network metrics and robust analysis.

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis

This study uses multi-omic approaches to analyze cellular and transcriptomic diversity in infrapatellar fat pad during knee osteoarthritis, identifying fibroblasts as key contributors to disease-related differences.

Curbing zoonotic disease spread in multi-host-species systems will require integrating novel data streams and analytical approaches: evidence from a scoping review of bovine tuberculosis

This paper reviews bTB research in multi-host systems, identifying gaps in studying human impacts, weather effects, and multi-host dynamics, and suggests integrating data and models for better control.

Assessing bias and robustness of social network metrics using GPS based radio-telemetry data

This study evaluates the bias and robustness of social network metrics using GPS telemetry data from five ungulate species, showing that global metrics are robust while local metrics are unreliable with low sampling.

Phenotypical mapping of TP53 unique missense mutations spectrum in human cancers

The paper maps the phenotypical effects of TP53 missense mutations across cancer types and tissues, identifying potential therapeutic targets.

Nanofluidic Device for Manipulation and Modification of DNA by Proteins

The paper introduces a nanofluidic device that enables real-time combinatorial exchange of buffers and dynamic DNA manipulation to study protein-DNA interactions.

In vitro and in vivo activity of Gepotidacin against drug-resistant mycobacterial infections

This study evaluates Gepotidacin's activity against drug-resistant mycobacteria, showing potent in vitro and in vivo efficacy, resistance bypass, and synergistic potential.

DNA capture and loop extrusion dynamics by cohesin-NIPBL

This study uses high-speed AFM to show cohesin-NIPBL captures DNA through arm extension and initiates loop extrusion without ATP hydrolysis, revealing mechanisms of DNA binding and loop formation.

Structural and Dynamic Basis of DNA Capture and Translocation by Mitochondrial Twinkle Helicase

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

Dynamic model of bovine brucellosis to investigate control strategies in endemic settings

The paper develops a stochastic, age-structured model to evaluate brucellosis control strategies in dairy cattle herds in India, finding that vaccination of replacement calves and long-term commitment to vaccination are key for effective control.

Metabolic switching and cell wall remodelling of Mycobacterium tuberculosis during bone tuberculosis

This study identifies transcriptomic changes and virulence factors in Mycobacterium tuberculosis during bone tuberculosis, revealing metabolic shifts and cell wall remodeling strategies for survival in the host.

Wnt signaling rescues amyloid beta induced stem cell loss

The paper shows that Wnt signaling rescues amyloid beta-induced stem cell loss by reducing inflammation and modulating aging-related genes.

Bioinspired Dual-Functional Solid Lipid Nanoformulations for Targeted Drug Delivery and Sustained Release for Enhancement of Potency of Albendazole, an Antihelminthic Drug

This paper develops bioinspired solid lipid nanoparticles for targeted drug delivery of albendazole, showing enhanced potency and sustained release against gastrointestinal helminths.

TIN2 facilitates TRF1-mediated trans- and cis-interactions on physiologically relevant long telomeric DNA

This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.

Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation.

This study uses omni ATAC-seq to map chromatin changes in naive CD4+ T-cells during activation, identifying enhancer regions and transcriptional signatures associated with T-cell responses.

Composite modeling of leaf shape across shoots discriminates Vitis species better than individual leaves

The paper models leaf shape changes across shoots in Vitis species and finds composite leaves better predict species identity than individual leaves.

Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

Selectivity among anti-σ factors by Mycobacterium tuberculosis ClpX influences intracellular levels of Extracytoplasmic Function σ factors

This study shows that mutations in the degron of anti-σ factors in M. tuberculosis affect ClpX-mediated proteolysis, thereby regulating the release of ECF σ factors and gene expression.