dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function
K. N. Mhatre, J. D. Murray, G. Flint, T. S. McMillen, G. Weber, M. Shakeri, A.-Y. Tu, S. Steczina, R. S. Weiss, D. Marcinek, C. E. Murry, D. Raftery, R. Tian, F. Moussavi-Harami, M. Regnier
This study shows that elevating dATP in cardiomyocytes improves cardiac function by enhancing contractility and metabolic flexibility through mitochondrial remodeling.
bioRxiv · Nov 7, 2022Physiology