Author

D. Marcinek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:metabolomics· 3 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Raftery· 2 shared M. D. Campbell· 2 shared P. S. Rabinovitch· 2 shared Y. A. Chiao· 2 shared A. T. Samuelson· 1 shared A.-Y. Tu· 1 shared C. E. Murry· 1 shared D. Djukovic· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPhysiology

D. Raftery

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Author profile →

4 papers

Recent·Most cited

Age and sex dependent effects of metabolic response to muscle contraction

M. D. Campbell, D. Djukovic, D. Raftery, D. Marcinek

This study investigates age and sex differences in mitochondrial substrate utilization during muscle contraction, finding that aged muscle shows altered fatty acid oxidation and metabolic responses to different exercise protocols.

bioRxiv · May 30, 2023 · PreprintPhysiology

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice

M. D. Campbell, A. T. Samuelson, Y. A. Chiao, M. T. Sweetwyne, W. C. Ladiges, P. S. Rabinovitch, D. Marcinek

This study shows that intermittent elamipretide injections in aged mice preserve exercise tolerance and skeletal muscle function but not heart or kidney function, unlike continuous treatment.

bioRxiv · Nov 29, 2022Physiology

dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function

K. N. Mhatre, J. D. Murray, G. Flint, T. S. McMillen, G. Weber, M. Shakeri, A.-Y. Tu, S. Steczina, R. S. Weiss, D. Marcinek, C. E. Murry, D. Raftery, R. Tian, F. Moussavi-Harami, M. Regnier

This study shows that elevating dATP in cardiomyocytes improves cardiac function by enhancing contractility and metabolic flexibility through mitochondrial remodeling.

bioRxiv · Nov 7, 2022Physiology

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

bioRxiv · Jan 2, 2020Physiology