Author

A.-Y. Tu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Moussavi-Harami· 2 shared G. Flint· 2 shared M. Regnier· 2 shared T. S. McMillen· 2 shared A. Martinson· 1 shared B. C. W. Tanner· 1 shared C. E. Murry· 1 shared C. Gao· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

F. Moussavi-Harami

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2 papers

Recent·Most cited

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

K. B. Kooiker, S. Mohran, K. L. Turner, W. Ma, G. Flint, L. Qi, C. Gao, Y. Zheng, T. S. McMillen, C. Mandrycky, A. Martinson, M. Mahoney-Schaefer, J. C. Freeman, E. G. Costales Arenas, A.-Y. Tu, , F. Moussavi-Harami

This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.

bioRxiv · Jan 31, 2023 · PreprintPhysiology

dATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function

K. N. Mhatre, J. D. Murray, G. Flint, T. S. McMillen, G. Weber, M. Shakeri, A.-Y. Tu, S. Steczina, R. S. Weiss, D. Marcinek, C. E. Murry, D. Raftery, R. Tian, F. Moussavi-Harami, M. Regnier

This study shows that elevating dATP in cardiomyocytes improves cardiac function by enhancing contractility and metabolic flexibility through mitochondrial remodeling.

bioRxiv · Nov 7, 2022Physiology