M. Shamay

KSHV genome harbors both constitutive and lytically induced enhancers

This study identifies constitutive and lytically induced enhancers in the KSHV genome using functional assays and CRISPR techniques, revealing a 'viral super-enhancer' that regulates latency-to-lytic transition.

Unidirectional protein recruitment is essential for viral latency

The paper demonstrates unidirectional protein recruitment between MeCP2 and LANA in KSHV latency, showing MeCP2 recruits LANA but not vice versa, and this is critical for viral maintenance.

RNA-sequencing analysis of a multistep and hit-and-run cell and animal model of KSHV tumorigenesis reveal the roles of mutations, CpG methylation, and viral-infection footprints in oncogenesis.

The paper uses RNA-seq and methylation analysis in a KSHV mouse model to show how viral infection and host mutations drive oncogenesis through epigenetic and genetic changes.