S. Williams

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

Characterization of immune cell populations in the tumor microenvironment of colorectal cancer using high definition spatial profiling

This study uses Visium HD spatial transcriptomics to map immune cell populations in colorectal cancer tumor microenvironments, identifying spatially distinct macrophage and T cell subpopulations.

AHR activation accelerates the resolution of TGF-β1 induced fibroblast activation and promotes alveolar type 1 cell regeneration in alveolar organoids

The paper identifies DB-11-BE87 as a compound that promotes AT1 cell regeneration by reducing TGF-β1-induced fibroblast activation through AHR activation in alveolar organoids.

The human complement factor B-C3b complex: Investigation of the interaction using C3b bound to thiol-Sepharose

This study investigates the interaction between factor B and C3b using competition assays, finding that specific antibodies can inhibit or enhance complex formation.

High resolution mapping of the breast cancer tumor microenvironment using integrated single cell, spatial and in situ analysis of FFPE tissue

This paper integrates single cell, spatial, and in situ technologies to analyze FFPE breast cancer tissue, revealing molecular insights into tumor subtypes and progression.

Metformin and guanylurea reduce survival, but have limited sublethal effects in larval zebrafish (Danio rerio)

This study tests the effects of metformin and guanylurea on zebrafish larvae, finding increased mortality and spinal curvature at high concentrations but limited sublethal effects at environmentally relevant levels.

Deep-Learning for Automated Markerless Tracking of Infants General Movements

This paper develops a deep-learning method for markerless tracking of infant general movements in video recordings, achieving high accuracy across multiple anatomical locations.

Assessing the activity of different plant-derived molecules and potential biological nitrification inhibitors on a range of soil ammonia- and nitrite- oxidizing strains

This study evaluates the activity of various plant-derived compounds as biological nitrification inhibitors on different soil ammonia- and nitrite-oxidizing microorganisms, identifying key compounds with varying effectiveness across species.

Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from Argentinian pig and dairy farms reveals animal-specific patterns of co-resistance and resistance mechanisms

This study identifies animal-specific patterns of third-generation cephalosporin resistance in E. coli from Argentinian pig and dairy farms, revealing differences in resistance mechanisms and co-resistance patterns.

Using passive acoustic monitoring to estimate the abundance of wide-ranging species in tropical rainforest ecosystems

This study uses passive acoustic monitoring to estimate the abundance of great green macaws in Costa Rica, finding a larger population than previously thought and highlighting new conservation areas.

Heterotopic reduction of forelimb progenitors underpins development of the vestigial emu wing; implications for vertebrate limb evolution

The paper identifies a heterotopic reduction of limb progenitor cells in the emu forelimb as the mechanism underlying its vestigial wing development, providing insights into limb evolution in tetrapods.

Improving the preclinical and clinical success rates of LMW drugs depends on radical revisions to the status quo scientific foundations of medicinal chemistry: a case study on COVID Mpro inhibition

This paper argues for a theoretical shift in medicinal chemistry to improve LMW drug success rates by applying Biodynamics to model cellular function and drug action in non-linear dynamic systems.

Remodelling of carbon metabolism during sulfoglycolysis in Escherichia coli

This study identifies metabolic changes in Escherichia coli when grown on sulfoquinovose versus glucose, revealing increased storage carbohydrate synthesis and reduced TCA cycle flux.

Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures

The paper identifies treatment-selected lethal prostate cancer clones through copy number analysis of metastases from multiple organs.

PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

This paper develops a new protocol for spatial transcriptomics analysis of FFPE PanIN specimens and integrates it with imaging and scRNA-seq to study the progression from PanIN to PDAC.

Digital data repository and automatic analysis framework for FDOPA PET neuroimaging

The paper develops a digital data repository and automated analysis framework for FDOPA PET neuroimaging to quantify dopamine synthesis capacity, showing high agreement with manual analysis and good reproducibility.

Structural, functional and computational studies of membrane recognition by Plasmodium Perforin-Like Proteins 1 and 2.

This study compares the membrane-binding properties of Plasmodium vivax PLP1 and PLP2 with Toxoplasma gondii PLP1 using structural and functional analyses.

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

Solvation dynamics-powered structure and function of multi-molecular cellular systems exemplified by non-equilibrium cereblon-degrader-CK1α ternary complex formation

The paper examines how solvation dynamics power structural and functional dynamics in multi-molecular complexes, exemplified by cereblon-degrader-CK1α interactions.

General structure-free energy relationships of hERG blocker binding under native cellular conditions

The paper analyzes hERG blocker binding using solvation field principles, showing correlations between solvation costs and blocker potency and safety.

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

A non-coding RNA network involved in KSHV tumorigenesis

The paper identifies a non-coding RNA network involving lncRNAs and miRNAs that modulate KSHV tumorigenesis pathways and develops therapeutic target signatures.

Recurrent Vulvovaginal Candidiasis; a dynamic interkingdom biofilm disease of Candida and Lactobacillus

This study investigates RVVC by analyzing the vaginal microbiome and interactions between Candida and Lactobacillus, finding reduced L. crispatus and increased L. iners, and showing Lactobacillus inhibition of Candida biofilm formation.

A geometric basis for surface habitat complexity and biodiversity

The paper develops a geometric theory to explain biodiversity in surface habitats, showing it explains 98% of variation in coral reefs.

MAVS regulates the quality of the antibody response to West-Nile Virus

This study shows that MAVS, an RLR signaling adaptor, is critical for the quality of the antibody response to WNV, as MAVS-deficient mice produced low-affinity IgM antibodies despite normal antigen levels.

RNA-sequencing analysis of a multistep and hit-and-run cell and animal model of KSHV tumorigenesis reveal the roles of mutations, CpG methylation, and viral-infection footprints in oncogenesis.

The paper uses RNA-seq and methylation analysis in a KSHV mouse model to show how viral infection and host mutations drive oncogenesis through epigenetic and genetic changes.

PDGFRA Defines the Mesenchymal Stem Cell Kaposi’s Sarcoma Progenitors by Enabling KSHV Oncogenesis in an Angiogenic Environment

The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.