S. Rosario

The paper identifies a non-coding RNA network involving lncRNAs and miRNAs that modulate KSHV tumorigenesis pathways and develops therapeutic target signatures.

The paper uses RNA-seq and methylation analysis in a KSHV mouse model to show how viral infection and host mutations drive oncogenesis through epigenetic and genetic changes.

The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.

The paper shows that FACT prevents chromatin destabilization in transformed cells, which is crucial for malignant transformation and survival.

This study identifies miR-96 as a regulator of RARγ expression, which in turn controls androgen signaling and prostate cancer progression through gene network alterations.