Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity.
E. R. Vander Mause, J. M. Baker, K. A. Dietze, S. V. Radhakrishnan, M. L. Olson, T. Iraguha, P. Davis, J. Panse, J. E. Marvin, M. Steinbach, D. P. Ng, C. S. Lim, D. Atanackovic, T. Luetkens
The paper engineers low-affinity CD229 CAR T cells with CJUN overexpression to reduce on-target off-tumor toxicity while preserving anti-tumor activity.
bioRxiv · Dec 6, 2021 · PreprintBioengineering