BioengineeringbioRxivPreprint
Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity.
E. R. Vander Mause, J. M. Baker, K. A. Dietze…·T. Luetkens
The paper engineers low-affinity CD229 CAR T cells with CJUN overexpression to reduce on-target off-tumor toxicity while preserving anti-tumor activity.