C. S. Lim

Computational Modeling of Stapled Coiled-Coil Inhibitors Against Bcr-Abl: Toward a Treatment Strategy for CML

The paper designs and evaluates stapled coiled-coil inhibitors against Bcr-Abl using computational modeling to improve stability and activity for CML treatment.

Phylogenetic analysis of human parainfluenza type 3 virus strains responsible for the outbreak during the COVID-19 pandemic in Seoul, South Korea

The paper analyzes HPIV3 strains from a Seoul outbreak, finding a new genetic cluster within subcluster C3 with unique amino acid substitutions.

Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity.

The paper engineers low-affinity CD229 CAR T cells with CJUN overexpression to reduce on-target off-tumor toxicity while preserving anti-tumor activity.

Effective Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations with In Vivo and In Vitro Validation

This paper develops a computational framework to simulate AVM haemodynamics and predict embolisation outcomes, validated with clinical and experimental data.

Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes

The paper identifies 6 novel and 6 previously known HBV splice variants across 4 genotypes using RNA-seq, revealing genotype-specific expression patterns and suggesting functional importance.

Analysis of fungal genomes reveals commonalities of intron loss/gain and functions in intron-poor species

The paper analyzes fungal genomes to show that intron loss/gain has occurred in multiple clades and that introns in intron-poor species are associated with gene expression.