Author

T. Luetkens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:CITE-seq· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

S. V. Radhakrishnan· 5 shared D. Atanackovic· 4 shared M. L. Olson· 4 shared J. M. Baker· 3 shared K. A. Dietze· 3 shared A. P. Rapoport· 2 shared A. Wang· 2 shared E. R. Vander Mause· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersBioengineering

S. V. Radhakrishnan

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5 papers

Recent·Most cited

Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function

K. A. Dietze, K. Nguyen, A. Pathni, F. Fazekas, W. Sun, E. Rosati, J. M. Baker, M. Galeana Figueroa, E. Gebru, D. Yamoah, R. Mulatu, A. Wang, A. P. Rapoport, D. Lum, X. Fan, , T. Luetkens

This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.

bioRxiv · Jun 11, 2024Bioengineering

Restricting CAR T Cell Trafficking Expands Targetable Antigen Space

E. A. Morales, K. A. Dietze, J. M. Baker, A. Wang, S. V. Avila, F. Iglesias, S. V. Radhakrishnan, E. Vander Mause, M. L. Olson, W. Sun, E. Rosati, S. L. Chidester, T. Iraguha, X. Fan, D. Atanackovic, T. Luetkens

The paper shows that modifying integrin-mediated adhesion in CAR T cells prevents CNS targeting while maintaining anti-tumor activity against Ewing sarcoma.

bioRxiv · Feb 8, 2024 · PreprintBioengineering

Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing

F. Iglesias, S. Weston, S. V. Avila, H. Zhou, S. Yousef, M. Fluchel, E. Morales, M. L. Olson, S. V. Radhakrishnan, T. Luetkens

This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.

bioRxiv · Jun 21, 2022 · PreprintBioengineering

Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activity.

E. R. Vander Mause, J. M. Baker, K. A. Dietze, S. V. Radhakrishnan, M. L. Olson, T. Iraguha, P. Davis, J. Panse, J. E. Marvin, M. Steinbach, D. P. Ng, C. S. Lim, D. Atanackovic, T. Luetkens

The paper engineers low-affinity CD229 CAR T cells with CJUN overexpression to reduce on-target off-tumor toxicity while preserving anti-tumor activity.

bioRxiv · Dec 6, 2021 · PreprintBioengineering

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing fratricide and antigen-negative tumor escape while preserving anti-tumor activity

M. L. Olson, E. R. Vander Mause, S. V. Radhakrishnan, J. D. Brody, A. P. Rapoport, A. L. Welm, D. Atanackovic, T. Luetkens

bioRxiv · Dec 5, 2021Bioengineering