Substrate conformational dynamics drive structure-specific recognition of gapped DNA by DNA polymerase
T. D. Craggs, M. Sustarsic, A. Plochowietz, M. Mosayebi, H. Kaju, A. Cuthbert, J. Hohlbein, L. Domicevica, P. C. Biggin, J. P. K. Doye, A. N. Kapanidis
This paper investigates how DNA polymerase I recognizes gapped DNA structures through conformational dynamics, revealing a bent DNA structure and using single-molecule FRET and simulations to support the findings.
bioRxiv · Feb 10, 2018Biophysics