J. P. K. Doye

This study investigates how thymine dimers affect DNA supercoiling and repair mechanisms through molecular dynamics simulations.

The paper shows that symmetry and simplicity in biological systems arise from algorithmic biases in evolution, not just natural selection, by testing predictions on protein complexes, RNA structures, and gene networks.

This paper investigates how DNA polymerase I recognizes gapped DNA structures through conformational dynamics, revealing a bent DNA structure and using single-molecule FRET and simulations to support the findings.