Click chemistry selectively activates an auristatin protodrug with either intratumoral or systemic tumor-targeting agents
J. M. McFarland, M. Aleckovic, G. Coricor, S. Srinivasan, M. Tso, J. Lee, T.-H. Nguyen, J. M. M. Oneto
This paper demonstrates the activation of a protodrug, SQP22, using click chemistry with tumor-targeting agents, showing anti-tumor effects in murine models with reduced toxicity.
bioRxiv · Mar 28, 2023Pharmacology & Toxicology