Rheological transition driven by matrix makes cancer spheroids resilient under confinement
T. Dutt, J. Langthasa, M. U, S. Mishra, S. Bothra, A. Vadaparty, P. Sen, R. Bhat
This study shows that ovarian cancer spheroids with an ECM coat (blastuloids) are more resilient under confinement than those without (moruloids) due to a rheological transition driven by the ECM-induced lumen.
bioRxiv · Feb 9, 2022Biophysics